Sanadihii la soo dhaafay, kororka hab-nololeedyada aan fiicnayn iyo cadaadiska bulshada ee sii kordhaya ee haweenka, heerka dhacdooyinka polycystic ovary syndrome (PCOS) ayaa noqday mid aad u cad.Daraasado shisheeye ayaa muujiyay in dhacdooyinka polycystic ovary syndrome (PCOS) ee haweenka da'da dhalmada ay aad u sarreeyaan ilaa 6% -15 %, halka Shiinaha, saamiga uu ka sarreeyo 6% -10 %.
Polycystic ovary syndrome waa cudur inta badan ku dhaca haweenka da'da dhalmada taasoo ay ugu wacan tahay cilladaha endocrine.Waxaa inta badan lagu muujiyaa gulukoos aan caadi ahayn iyo dheef-shiid kiimikaad ee dufanka iyo cilladda taranka.Shuruudaha ogaanshaha bukaan-socodka ayaa ah xanuunka heerka hoormoonka (androgen sare) , khalkhalgelinta cilladaha ugxan-sidaha iyo isbeddellada polycystic ugxan-sidaha, iyo inta badan haweenka PC COS waxay leeyihiin astaamo dheef-shiid kiimikaad xun, sida caabbinta insulin, buurnaanta, iyo steatosis cagaarshow.
Hadda, waxaa jira daawooyin yar oo loogu talagalay daaweynta PCOS.Habka caadiga ah waa in la hagaajiyo PCOS iyada oo la beegsanayo lagana hortagayo xad-dhaafka androgen-ka ee daawooyinka lidka-androgen-ka.Si kastaba ha ahaatee, waxaa sidoo kale jira caddayn ah in daawooyinka anti-androgen ay leeyihiin sunta beerka oo xooggan, sidaas darteed isticmaalkoodu waa xaddidan yahay.Sidaa darteed, aad bay muhiim u tahay in la raadiyo walaxda dabiiciga ah iyada oo aan lahayn waxyeellooyin si loo beddelo daawooyinka hadda jira.
Daraasad ay dhowaan samaysay Jaamacadda New South Wales ee Australia waxay ogaatay in polycystic ovary syndrome ay la xiriirto yaraanta NAD +, natiijada cilmi-baarista waxaa lagu daabacay joornaalka sayniska "Molecular Metabolism" .
Kooxda cilmi-baadhistu waxay markii ugu horreysay ku dhejiyeen dihydrotestosterone (DHT) subcutaneously ee jiirarka dheddigga ka hor iyo ka dib qaan-gaarnimada si ay u abuuraan qaabka jiirka PC COS, ka dibna 8 toddobaad ka dib daaweynta NMN, insulin soonka iyo HOMA ogaanshaha caabbinta insulinta, tijaabada dulqaadka gulukooska, dufanka Ka dib baaritaannada noocaas ah Sida histomorphometry, natiijooyinka tirakoobku waxay muujinayaan:
1. N MN waxay soo celisaa heerka N AD + heerka muruqa jiirarka P COS
Waxaa la ogaaday in heerka NAD + ee muruqa PCOS uu si weyn hoos ugu dhacay, iyo heerka NAD ee muruqa jiirarka PCOS waxaa soo celiyay quudinta NMN.
2. NMN waxay hagaajisaa caabbinta insulin iyo cayilka jiirarka PCOS
Heerarka insulinta ay keentay DHT wax ka badan labanlaabmay jiirarka PCOS ee sooman, oo laga yaabo inay ka tarjumayso caabbinta insulin.Marka la quudiyo NMN, waxaa la ogaaday in heerka insulinta soonka lagu soo celiyay heerka u dhow jiirarka caadiga ah.Intaa waxaa dheer, miisaanka jidhka ee jiirarka PCOS wuxuu kordhay 20%, iyo tirada baruurta ayaa si aad ah u kordhay.
3. NMN waxay soo celisaa dhigaalka dufanka beerka ee aan caadiga ahayn ee jiirarka PCOS
Mid ka mid ah sifooyinka polycystic ovary syndrome waa dufanka ku jira beerka iyo kicinta beerka dufanka leh.Ka dib qaadashada NMN, kaydinta dufanka beerka ee aan caadiga ahayn ee jiirarka PCOS ayaa ku dhawaad la tirtiray, triglycerides ee beerka ayaa ku soo laabtay heerka jiirarka caadiga ah.
Gabagabadii, heerka NAD + ee muruqa PCOS si weyn ayaa loo dhimay, xaalada PCOS-na waxaa la yareeyay iyada oo la kabay NMN, horudhaca NAD +, taas oo noqon karta istaraatiijiyad daweyn oo suurtagal ah oo lagu daweynayo PCOS.
tixraacyo:
[1]Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Hoos u dhaca muruqa NAD + ee hyperandrogenism PCOS mouse mouse: Doorka suurtagalka ah ee habdhiska dheef-shiid kiimikaadka.Mol Metab.2022 Seb 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub ka hor daabacaadda.PMID: 36096453.
Waqtiga boostada: Nov-17-2022