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Horumarka cilmi-baarista ee enzymatic synthesis ee horu-dhacyada suurtagalka ah ee Clenbuterol ee iskaashiga u dhexeeya Jaamacadda Sayniska iyo Teknolojiyada Norway iyo Shangke Biomedical

Clenbuterol, waa β2-adrenergic agonist (β2-adrenergic agonist), oo la mid ah ephedrine (Ephedrine), ayaa inta badan loo isticmaalaa kiliinikada si loo daaweeyo cudurrada sambabada ee joogtada ah (COPD), Waxaa sidoo kale loo isticmaalaa bronchodilator si loo yareeyo xumeynta daran ee neefta.Horraantii 1980-meeyadii, shirkadda Maraykanka ee Cyanamid waxay si lama filaan ah u ogaatay in ay leedahay saameyn cad oo kor u qaadida koritaanka, hagaajinta heerka hilibka caatada ah iyo yaraynta baruurta, sidaas darteed waxaa loo isticmaali jiray clenbuterol ee xanaanada xoolaha.Si kastaba ha ahaatee, ay sabab u tahay waxyeelo ay, Bulshada Yurub mamnuucay isticmaalka clenbuterol sida lagu daro feed ah tan iyo January 1, 1988. Waxaa la mamnuucay FDA ee 1991. In 1997, Wasaaradda Beeraha ee Jamhuuriyadda Dadka ee Shiinaha si adag loo mamnuucay. isticmaalka hormoonnada beta-adrenergic ee quudinta iyo wax soo saarka xanaanada xoolaha, iyo Clenbuterol hydrochloride kaalinta koowaad.

Si kastaba ha ahaatee, jinsiyadda Clenbuterol ayaa dhawaan la muujiyay si loo yareeyo khatarta cudurka Parkinson.Si loo xaqiijiyo taas oo (ama labadaba) isomers soo saaro saamaynta this, enantiomer Clenbuterol saafi ah u baahan yahay in si gaar ah loo barto.

Maqaal dhowaan ah, kooxda cilmi-baarista ee Elisabeth Egholm Jacobsen oo ka tirsan Waaxda Chemistry, Jaamacadda Norway ee Sayniska iyo Teknolojiyadda, oo kaashanaysa Dr. Zhu Wei ee Shangke Bio, ayaa kiciyay isku-darka ketoreductase KRED iyo cofactor nicotinamide adenine dinucleoside phosphate (NADPH) ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;iyo (S) -N- (2 waxaa lagu soo saaray nidaam isku mid ah,6-Dichloro-4- (1-hydroxyethyl) phenyl) acetamide, ee> 98%.Labada dhexdhexaadiye ee kor ku xusan waa horudhacyo suurtagal ah oo ah isomers clenbuterol.Ketoreductase ES-KRED-228 loo isticmaalo daraasaddan waxay ka timid Shangke Biopharmaceutical (Shanghai) Co., Ltd. Natiijada cilmi-baarista "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol iyo Other -2-Agonists" ayaa lagu daabacay "Catalysts" on November 4, 2018.

Horumarka cilmi baarista ee isku-dhafka enzymatic

Waqtiga boostada: Agoosto-26-2022