Ketoreductase (KRED)
KRED oo ka socota SyncoZymes: Waxaa jira 191 nooc oo ah badeecooyinka ensaymka KRED (Lambarka ES-KRED-101~ES-KRED-291) oo ay samaysay SyncoZymes. SZ-KRED waxaa si weyn loogu isticmaali karaa yaraynta gobollada iyo kuwa stereoselective ee aldehydes, beta-ketone esters, α-ketone esters iyo ketones.
Nooca falgalka kicinta:
| Ensaymyada | Koodhka Badeecada | Faahfaahinta |
| Budada Ensaymka | Budada Ensaymka | set ah 187 Ketoreductases, 50 mg midkiiba 187 shay * 50mg / shay, ama tiro kale |
| Qalabka Baaritaanka (SynKit) | ES-KRED-18100 | set ah 181 Ketoreductases, 1 mg midkiiba 181 shay * 1mg / shay |
★ Gaar ahaansho sare oo substrate ah.
★ Xulasho xooggan oo ku saabsan chiral.
★ Waxtarka sare ee beddelka.
★ Wax soo saar yar.
★ Xaalado falcelin fudud.
★ Deegaanka u wanaagsan.
➢ Baaritaanka ensaymka waa in loo sameeyaa substrate-yo gaar ah sababtoo ah gaar ahaanshaha substrate-ka, oo la helo ensaym kiciya substrate-ka bartilmaameedka leh saameynta katalytic-ga ugu fiican.
➢ Weligaa ha taaban xaalado daran sida: heerkul sare, pH sare/hoose iyo dareere dabiici ah oo leh xoog badan.
➢ Caadiyan, nidaamka falcelinta waa inuu ku jiraa substrate, xalka kaydka, coenzymes (NAD(H) ama NADP(H)), nidaamka dib u soo noolaynta coenzyme (tusaale ahaan gulukooska iyo glucose dehydrogenase).
➢ KRED waa in lagu daraa habka falcelinta ugu dambeeya, ka dib marka pH iyo heerkulka la hagaajiyo xaaladda falcelinta.
➢ Dhammaan noocyada KRED waxay leeyihiin xaalado kala duwan oo falcelin ah oo ugu wanaagsan, sidaa darteed mid kasta oo ka mid ah waa in si gaar ah loo bartaa.
Tusaale 1aad(1):
Tusaale 2(2):
1. Li Z, Liu WD, Chen X, iyo tall. Tetrahedron, 2013, 69, 3561-3564.
2. Ni Y, Li CX, Ma HM, iyo Tal. Appl Microbiol Biotechnol, 2011, 89: 1111-1118.
