Cytochrome P450 monooxygenase (CYP)

Sharaxaad Gaaban:

Ku saabsan CYP

ES-CYPs: Waa nooc ka mid ah enzymes redox oo leh mercaptan-heme oo ah xarun firfircoon si ay u kiciso wareejinta oksijiinta.Waxay yihiin oxygenases-ka-baxa waxayna u baahan yihiin heme si ay u dhaqaajiyaan ogsijiinta.

Cytochrome P450 monooxygenase katalyze oxidation, Epoxidation iyo hydroxylation of alkyl, hydroxylation iyo oxidation of ammonia, oxidation of baaruud, dealkylation (oxygen, baaruud, ammonia), fuuqbaxa oxidative, deamination iyo dehalogenation.
Waxaa jira 8 nooc oo cytochrome P450 monooxygenase ah (Lambarka ES-CYP-101-ES-CYP-108) oo ay soo saartay SyncoZymes.

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Faahfaahinta Alaabta

Tags Product

Ku saabsan CYP:

Nooca falcelinta catalytic:

Macluumaadka Alaabta:

Enzymes	Qalabka Baaritaanka (SynKit)	Tilmaamid
Budada Enzyme	ES-CYP-101~ ES-CYP-108	8 Cytochrome P450 Monooxygenases, 50 mg midkiiba 8 shay * 50mg / shay, ama tiro kale
Qalabka Baaritaanka (SynKit)	ES-CYP-800	8 Cytochrome P450 Monooxygenases, 1mg kasta 8 shay * 1mg / shay

Faa'iidooyinka:

★ spectrum substrate ballaaran.
★ beddelaad sare.
★ Alaabooyin ka yar
★ Xaalado falcelin fudud.
★ deegaan ahaan.

Tilmaamaha isticmaalka:

Caadiyan, habka falcelinta waa in lagu daraa substrate, xal wax-qaboojin ah (PH falcelinta ugu fican ee enzyme), coenzyme (NAD (H) ama NADP(H)), nidaamka dib u soo kabashada coenzyme (tusaale gulukoosta iyo gulukooska dehydrogenase) iyo ES-CYP.coenzyme iyo nidaamka dib u soo kabashada coenzyme waxaa lagu bedeli karaa hydrogen peroxide habka qayb ahaan falcelinta.
➢ Dhammaan noocyada ES-CYPs ee u dhigma xaaladaha kala duwan ee falcelinta ugu wanaagsan waa in si gaar ah loo darso.
➢ Substrate-ka sare ama badeecada leh ayaa laga yaabaa inay hakiso dhaqdhaqaaqa ES-CYP.Si kastaba ha ahaatee, xannibaadda waxaa lagu nafisi karaa marka lagu daro qayb ka mid ah substrate.

Tusaalooyinka Codsiga:

Tusaale 1⁽¹⁾:

Tusaale 2⁽²⁾:

Tusaale 3⁽³⁾:

Tusaale 4⁽⁴⁾:

Kaydinta:

Ka dhig 2 sano ka hooseeya -20 ℃.

Fiiro gaar ah:

Weligaa ha la xiriirin xaaladaha ba'an sida: heerkulka sare, pH sare/hoose iyo dareeraha organic-fiirsashada sare leh.

Tixraacyo:

1. Zaretzki J, Matlock M, iyo Swamidass S JJ Chem.Inf.Qaabka, 2013, 53, 3373-3383.
2. Gannett P M., Kabulski J, Perez F A., iyo Tal.J. AmChem.Soc., 2006, 128 (26), 8374-8375.
3. Cryle M J., Matovic N J., iyo De Voss J J. Org.Lett., 2003, 5 (18), 3341-3344.
4. Kawauchi, H., Sasaki, J., Adachi, T., e tal.Biochim.BiophysActa, 1994, 1219, 179.
5. Yasutake, Y., Fujii, Y.;Cheon, WK iyo tall.Acta Crystallogr.2009, 65, 372.