Amine Dehydrogenase (AmDH)
Sharaxaad Gaaban:
Ku saabsan Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): ensaymes oo kicin kara ammoation kooxda karbonyl oo u yarayn karta kooxda amino.Waa koenzyme NADH ku tiirsanaanta enzyme, NADH waxay u shaqeysaa sidii gudbiye haydrojiin ah.Waxaa jira 4 nooc oo ah alaabada enzyme AmDH (Lambarka sida ES-AmDH101～ES-AmDH104) oo ay samaysay SyncoZymes, kaas oo loo isticmaali karo dib-u-soo-doorasho-soo-saarka aldehyde iyo ketones.
Nooca falcelinta catalytic:
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iimayl:lchen@syncozymes.com
★ gaar ahaan substrate-ka sare.
★ Xulasho xoog leh oo chiral ah.
★ beddelaad sare.
★ Alaabooyin ka yar
★ Xaalado falcelin fudud.
★ deegaan ahaan.
➢ Caadiyan, habka falcelinta waa in uu ku jiraa substrate, xal buffer, enzyme, coenzyme iyo nidaamka dib u soo kicinta coenzyme (tusaale gulukoosta iyo gulukoosta dehydrogenase).
➢ AmDH waa in lagu daraa ugu dambayn habka falcelinta, ka dib marka pH iyo heerkulka lagu hagaajiyo xaaladda falcelinta.
Tusaalaha 1 (Synthesis of amines chiral u dhiganta oo hoos u dhigaysa ketones alkyl aryl)(1):
Ka dhig 2 sano ka hooseeya -20 ℃.
Weligaa ha la xiriirin xaaladaha ba'an sida: heerkulka sare, pH sare/hoose iyo dareeraha organic-fiirsashada sare leh.
1. Kong W, Liu Y, Huang C, iyo al.Daabacaada Caalamiga ah ee Angewandte Chemie, 2022: e202202264.
