Amine Dehydrogenase (AmDH)
Sharaxaad Gaaban:
Ku saabsan Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): ensaym kicin kara ammonia-ga kooxda carbonyl oo u dhimi kara kooxda amino. Waa ensaym ku tiirsan coenzyme NADH, NADH-na waxay u dhaqantaa sidii gudbiye haydarojiin ah. Waxaa jira 4 nooc oo ah alaabada ensaymka AmDH (Lambarka sida ES-AmDH101～ES-AmDH104) oo ay samaysay SyncoZymes, kaas oo loo isticmaali karo isku-darka regioselective ama stereoselective reductive ee aldehydes iyo ketones.
Nooca falgalka kicinta:
Moobayl/Wechat/WhatsApp: +86-13681683526
Iimayl:lchen@syncozymes.com
★ Gaar ahaansho sare oo substrate ah.
★ Xulasho xooggan oo ku saabsan chiral.
★ Beddel sare.
★ Wax soo saar yar.
★ Xaalado falcelin fudud.
★ Deegaanka u wanaagsan.
➢ Caadiyan, nidaamka falcelinta waa inuu ku jiraa substrate, xalka kaydka, ensaymka, coenzyme iyo nidaamka dib u soo noolaynta coenzyme (tusaale ahaan gulukooska iyo glucose dehydrogenase).
➢ AmDH waa in lagu daraa nidaamka falcelinta ugu dambeeya, ka dib marka pH iyo heerkulka la hagaajiyo xaaladda falcelinta.
Tusaale 1 (Isku-darka amiinada chiral ee u dhigma iyadoo la yareynayo amin-ka alkyl aryl ketones)(1):
Ku hay heerkul ka hooseeya -20 ℃ 2 sano.
Weligaa ha taaban xaalado daran sida: heerkul sare, pH sare/hoose iyo dareere dabiici ah oo xoog badan.
1. Kong W, Liu Y, Huang C, iyo al. Daabacaada Caalamiga ah ee Angewandte Chemie, 2022: e202202264.
