Cyclooxygenase (COX)

Sharaxaad Gaaban:

Ku saabsan Cyclooxygenase

ES-COX (Cyclooxygenase): wuxuu kiciyaa beddelka isku-xidhka C=C una beddelaa epoxide. Waxaa jira 11 nooc oo ah alaabada ensaymka COX (Lambarka sida ES-COX101~ ES-COX-111) oo ay samaysay SyncoZymes. Sida laga soo xigtay habka kala duwan ee katalytic-ga, COX ee SyncoZymes wuxuu u qaybsan yahay haloperoxidase iyo styrene monooxygenase. ES-COX101, 102, 107-111 waxay ka tirsan yihiin haloperoxidase, halka ES-COX103-106 ay ka tirsan tahay styrene monooxygenase.

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Faahfaahinta Badeecada

Calaamadaha Alaabta

Ku saabsan Cyclooxygenase:

Nooca falgalka kicinta:

Haloperoxidase:

Styrene monooxygenase:

Macluumaadka Badeecada:

Ensaymyada	Koodhka Badeecada	Faahfaahinta
Budada Ensaymka	ES-COX-101~ ES-COX-110	set 10 NADH Cyclooxygenase ah, 50 mg midkiiba 10 shay * 50mg / shay, ama tiro kale

Faa'iidooyinka:

★ Gaar ahaansho sare oo substrate ah.
★ Xulasho xooggan oo ku saabsan chiral.
★ Beddel sare.
★ Wax soo saar yar.
★ Xaalado falcelin fudud.
★ Deegaanka u wanaagsan.

Tilmaamaha isticmaalka:

➢ Caadiyan, nidaamka falgalka haloperoxidase waxaa ka mid ah: substrate, buffer, ensaym, H2O2 iyo halogen ion. Nidaamka falgalka styrene monooxygenase waxaa ka mid ah substrate, buffer, ensaym, coenzyme iyo coenzyme dib u soo noolaynta.
➢ COX waa in lagu daraa habka falcelinta ugu dambeeya, ka dib marka pH iyo heerkulka la hagaajiyo xaaladda falcelinta.

Tusaalooyinka Codsiga:

Tusaale 1 (Isku-darka noocyada kala duwan ee epoxy styrene ee laga soo qaatay noocyada kala duwan ee styrene)⁽¹⁾:

Fiiro gaar ah: tusaalooyinka codsiga iyo tixraacyada waxaa loogu talagalay inay tilmaamaan baaxadda codsiga ee COX si loo fududeeyo fahamka, mana la jaanqaadaan ensaymka gaarka ah ee SyncoZymes.