Sawirka Lagu Soo Bandhigay Esterase&Lipase (PLE&CALB)

Esterase iyo Lipase (PLE&CALB)

Sharaxaad Gaaban:

Ku saabsan Esterase & Lipase

ES-PLES: Nooc ka mid ah hydrolases-ka kaas oo kiciya sameynta iyo jabka xidhmooyinka ester-ka. Waxay ka qayb qaadan karaan noocyo badan oo falgallo bayooloji ah, sida esterification, transesterification iyo hydrolysis. Waxaa si weyn loogu isticmaalaa dhinacyo badan sida habaynta cuntada, warshadaha kiimikada, bayomedicine, daawada chiral iyo daaweynta deegaanka.

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Iimayl:lchen@syncozymes.com

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Faahfaahinta Badeecada

Calaamadaha Alaabta

Ku saabsan Esterase & Lipase:

Waxaa jira 26 nooc oo ah badeecooyinka ensaymka PLE (Lambarka ES-PLE-101～ES-PLE-126) oo ay samaysay SyncoZymes. ES-PLE waxaa loo isticmaali karaa hydrolysis-ka isku-dhafka aliphatic iyo ester, ama xallinta regioselective iyo stereoselective si loo sameeyo asiidhyada chiral iyo waxyaabaha ka soo baxa.

Nooca falgalka kicinta:

Faa'iidooyinka:

★ Gaar ahaansho sare oo substrate ah.
★ Xulasho xooggan oo ku saabsan chiral.
★ Beddel sare.
★ Wax soo saar yar.
★ Xaalado falcelin fudud.
★ Deegaanka u wanaagsan.

Tilmaamaha isticmaalka:

➢ Caadiyan, nidaamka falgalka waa inuu ku jiraa substrate, xalka kaydka iyo ES-PLE. Esterification-ka qaar ka mid ah ES-PLEs waxaa lagu sameeyaa marxaladda dabiiciga ah.
➢ Dhammaan noocyada ES-PLE ee u dhigma xaaladaha kala duwan ee falcelinta ugu wanaagsan waa in si gaar ah loo bartaa.

Tusaalooyinka Codsiga:

Tusaale 1 (Biosynthesis of Pregabalin Intermediate)⁽¹⁾:

Tusaale 2⁽²⁾:

Tusaale 3⁽³⁾:

Tusaale 4⁽⁴⁾:

Kaydinta:

Ku hay heerkul ka hooseeya -20 ℃ 2 sano.

Feejignaan:

Weligaa ha taaban xaalado daran sida: heerkul sare, pH sare/hoose.

Tixraacyada:

1. Xu FX, Chen SY, Xu G, iyo tal. Appl. Biotechnol Bioproc E, 1988, 54(4): 1030.
2. Huang, FC, Lee, LF, Mittal, RSD iyo tal. J. Am Chem.Soc, 1975, 97, 4144.
3. Kielbasinski, P., Goralczyk, P., Mikolajczyk, M., e tal. Synlett, 1994, 127.
4. Gais, HJ, Griebel, C., Buschmann, H. Tetrahedron: Asymmetry 2000, 11, 917

Kii hore: Epoxide hydrolase (EH)

Xiga: Qaabaynta dehydrogenase (FDH)

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