Imine reductase (IRED)
Sharaxaad Gaaban:
Ku saabsan Imine reductase
ES-IRED: Waa nooc ka mid ah ensaymes kuwaas oo kicinaya dhimista curaarta C=N ee curaarta CN.Waxay iska leedahay enzyme redox, oo leh coenzyme NADPH ee gaadiidka hydrogen.Marka loo eego doorbidida chiral ee alaabooyinka, waxaa loo qaybin karaa R-IRED iyo S-IRED.Syncozymes waxay soo saartay 15 imine reductases (lambareeyay ES-IRED-101-ES-IRED-115), kuwaas oo si ballaaran loogu isticmaali karo hoos u dhigista dib-u-doorashada iyo hoos u dhigista stereosective ee imines si loogu diyaariyo amines chiral.
Nooca falcelinta catalytic:
Mobile/Wechat/WhatsApp: +86-13681683526
iimayl:lchen@syncozymes.com
| Enzymes | Koodhka badeecada | Tilmaamid |
| Budada Enzyme | ES-IRED-101~ ES-IRED-114 | qayb ka mid ah 14 Imine Reductase, 50 mg midkiiba |
| 96-Hagaag Qalabka Baaritaanka Enzyme-ga | ES-IRED-1400 | qayb ka mid ah 14 Imine Reductase, 1 mg midkiiba |
★ gaar ahaan substrate-ka sare.
★ Xulasho xoog leh oo chiral ah.
★ beddelaad sare.
★ Alaabooyin ka yar
★ Xaalado falcelin fudud.
★ deegaan ahaan.
➢ Caadiyan, habka falcelinta waa in uu ku jiraa substrate, xal buffer, enzyme, coenzyme, iyo nidaamka dib u soo kicinta coenzyme.
➢ Dhammaan noocyada ES-IRED ee u dhigma xaaladaha kala duwan ee falcelinta ugu wanaagsan waa in si gaar ah loo darso.
➢ Substrate-ka sare u kaca ama badeecada leh ayaa laga yaabaa inay hor istaagto dhaqdhaqaaqa ES-IRED.Si kastaba ha ahaatee, xannibaadda waxaa lagu nafisi karaa marka lagu daro qayb ka mid ah substrate.
Tusaale 1 (Biosynthesis of chiral 2-methyl pyrrolidine)(1):
Tusaale 2 (Biosynthesis of amine secondary)(2):
Tusaalaha 3 ( Yaraynta Imiinada meertada ah)(3):
Ka dhig 2 sano ka hooseeya -20 ℃.
Weligaa ha la xiriirin xaaladaha ba'an sida: heerkulka sare, pH sare/hoose iyo dareeraha organic-fiirsashada sare leh.
1. Scheller PN, Fademrecht S, Hofelzer S, iyo al.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, iyo al.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, iyo al.Adv.Synth.Catal.2015, 357, 1692-1696.
