Imine reductase (IRED)
Sharaxaad Gaaban:
Ku saabsan Imine reductase
ES-IRED: Nooc ka mid ah ensaymyada kiciya hoos u dhigista xidhmada C=N ee xidhmada CN. Waxay ka tirsan tahay redox enzyme, oo leh coenzyme NADPH oo loogu talagalay gaadiidka haydarojiin. Sida waafaqsan doorbidka chiral ee badeecadaha, waxaa loo qaybin karaa R-IRED iyo S-IRED. Syncozymes waxay sameeyeen 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), kuwaas oo si weyn loogu isticmaali karo dhimista regioselective iyo stereoselective ee imines si loogu diyaariyo chiral amines.
Nooca falgalka kicinta:
Moobayl/Wechat/WhatsApp: +86-13681683526
Iimayl:lchen@syncozymes.com
| Ensaymyada | Koodhka Badeecada | Faahfaahinta |
| Budada Ensaymka | ES-IRED-101~ ES-IRED-114 | set 14 Imine Reductase ah, midkiiba 50 mg |
| Qalabka Baaritaanka Ensaymka 96-Wel | ES-IRED-1400 | set ah 14 Imine Reductase, 1 mg midkiiba |
★ Gaar ahaansho sare oo substrate ah.
★ Xulasho xooggan oo ku saabsan chiral.
★ Beddel sare.
★ Wax soo saar yar.
★ Xaalado falcelin fudud.
★ Deegaanka u wanaagsan.
➢ Caadiyan, nidaamka falgalka waa inuu ku jiraa substrate, xalka kaydka, ensaymka, coenzyme, iyo nidaamka dib u soo noolaynta coenzyme.
➢ Dhammaan noocyada ES-IRED ee u dhigma xaaladaha kala duwan ee falcelinta ugu wanaagsan waa in si gaar ah loo barto.
➢ Substrate-ka ama badeecadda leh feejignaan sare ayaa laga yaabaa inay joojiso dhaqdhaqaaqa ES-IRED. Si kastaba ha ahaatee, joojinta waxaa lagu yareyn karaa iyadoo lagu daro substrate-ka dufcaddii.
Tusaale 1(Biosynthesis of chiral 2-methyl pyrrolidine)(1):
Tusaale 2 (Biosynthesis of secondary amine)(2):
Tusaale 3 (Yaraynta Imines-ka Wareega ah)(3):
Ku hay heerkul ka hooseeya -20 ℃ 2 sano.
Weligaa ha taaban xaalado daran sida: heerkul sare, pH sare/hoose iyo dareere dabiici ah oo xoog badan.
1. Scheller PN, Fademrecht S, Hofelzer S, iyo al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, iyo kuwo kale. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, iyo al. Adv. Synth. Catal. 2015, 357, 1692-1696.
