β-Nicotinamide adenine dinucleotide (asiidh bilaash ah) (NAD)
NAD waa coenzyme aad ugu badan ee dehydrogenase ee noolaha noolaha.Waxay ka qaybqaadataa falcelinta redox ee noolaha, waxayna u qaadaa oo u gudbisaa elektaroonnada walxaha falcelinta.Dehydrogenase waxay door muhiim ah ka ciyaartaa dheef-shiid kiimikaadka aadanaha.Dhaqdhaqaaqyada dheef-shiid kiimikaadka aasaasiga ah ee jidhka bini'aadamka, sida burburka borotiinka, karbohaydraytyada, iyo burburka dufanka, si caadi ah looma fulin karo iyada oo aan la helin fuuqbaxa, dadkuna waxay lumin doonaan calaamadaha muhiimka ah.Iyo sababta oo ah isku dhafka NAD iyo dehydrogenase waxay kor u qaadi karaan dheef-shiid kiimikaad, sidaa darteed NAD waa qayb lagama maarmaan ah oo ka mid ah jidhka bini'aadamka.Marka loo eego isticmaalka alaabta, waxa loo qaybin karaa darajooyinka soo socda: darajada biotransformation, darajada reagent ogaanshaha, heerka cuntada caafimaadka, API iyo diyaarinta alaabta ceeriin.
| Magaca Kiimikada | Nikotinamide adenine dinucleotide (ashito xor ah) |
| La mid ah | β-Nicotinamide adenine dinucleotide |
| Lambarka CAS | 53-84-9 |
| Miisaanka Molecular | 663.43 |
| Qaanuunka molecular | C21H27N7O14P2 |
| EINECS wuxuu leeyahay: | 200-184-4 |
| barta dhalaalaysa | 140-142 °C (decomp) |
| heerkulka kaydinta. | -20°C |
| milmayn | H2O: 50 mg/ml |
| qaab | Budada |
| midab | Caddaan |
| Merck | 14,6344 |
| BRN | 3584133 |
| Xasilooni | DegganHygroscopicAan ku habboonayn walxaha oksaydhaynta ee xooggan. |
| InChiKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Shayga Tijaabada | Tilmaamaha |
| Muuqashada | Caddaan iyo budo crystalline ah |
| Falanqaynta spectral UV ε260 nm iyo pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Solubility | 25mg/mL 25mg/mL oo biyo ah |
| Nuxurka (oo lagu falanqeeyo enzymatic oo leh ADH oo ah pH 10, iyadoo la adeegsanayo spectrophotometer, abs.340nm, oo ku salaysan anhydrous) | ≥98.0% |
| Qiimaynta (by HPLC, oo ku salaysan anhydrous) | 98.0 ~ 102.0% |
| Daahirnimada (waxaa leh HPLC,% area) | ≥99.0% |
| Waxyaabaha biyaha ka kooban (waxaa qoray KF) | ≤3% |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Si adag ugu xidh mugdiga, si aad u kaydiso wakhti dheer ku hayso 2 ~ 8 ℃.
Darajada Biotransformation: Waxaa loo isticmaali karaa isku-darka biocatalytic ee dhexdhexaadiyeyaasha dawooyinka iyo API-yada, inta badan leh enzymes-ka-taliya, sida ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), gulukoos dehydrogenase (FDH) GDH), iwm, kuwaas oo iska kaashan kara si loogu beddelo dhexdhexaadiyeyaasha amino acid kala duwan iyo daawooyinka kale ee la xidhiidha.Waqtigan xaadirka ah, warshado badan oo dawooyinka gudaha ah ayaa bilaabay inay adeegsadaan beddelka enzyme bayooloji, iyo baahida suuqa ee NAD + ayaa si dhakhso leh u kordheysa.
Darajada reagent ogaanshaha: Lagu daray noocyo kala duwan oo ensaymes ogaanshaha, sida alaabta ceeriin ee xirmooyinka ogaanshaha.
Heerka cuntada caafimaadka: NAD waa coenzyme of dehydrogenase.Waxay ka ciyaartaa door aan la bedeli karin ee glycolysis, gluconeogenesis, wareegga tricarboxylic acid, iyo silsiladda neefsiga, waxay door muhiim ah ka ciyaartaa wax soo saarka tamarta, waxayna ka caawisaa wax soo saarka L-dopa, kaas oo noqda dopamine Neurotransmitters.Gaar ahaan sanadihii ugu dambeeyay, waxaa la ogaaday in ay tahay "matoorka" iyo "shidaalka" habka hagaajinta dhaawaca unugyada.Sida laga soo xigtay cilmi-baarista, kaabidda coenzymes (oo ay ku jiraan NMN, NR, NAD, NADH) in vitro waxay kor u qaadi kartaa awoodda antioxidant ee unugyada unugyada, waxay joojin kartaa calaamadaha apoptosis, dib u soo celinta shaqada unugyada caadiga ah, ka hortagga dhacdooyinka cudurka ama waxay joojinayaan horumarka cudurka.
Intaa waxaa dheer, coenzymes waxay kor u qaadi kartaa awoodda jawaab celinta difaaca iyagoo kicinaya oo kor u qaadaya korriinka unugyada difaaca jirka, soo saarista arrimo anti-bararka iyo xakameynta unugyada T-da ee nidaamsan.Nicotinamide dinucleotide oxidation state (NAD +) waa coenzyme laga helo dhammaan unugyada noolaha.Waxay ka ciyaartaa door muhiim ah boqolaal hababka dheef-shiid kiimikaadka ee unugyada, waxay ka qaybqaataa kumanaan falcelin jireed, waana xubinta ugu muhiimsan ee silsiladda gaadiidka elektaroonigga ah.Ku-deeqaha hydrogen;Isla mar ahaantaana, coenzyme I wuxuu u dhaqmaa sidii substrate-ka kaliya ee enzymes-ka laxiriira ee jirka, isagoo gacan ka geysanaya inuu ilaaliyo dhaqdhaqaaqa enzymes-ka.
Nicotinamide mononucleotide (NMN) waa xarunta hore ee nicotinamide adenine dinucleotide oxidation state (NAD +), kaas oo ku lug leh isku-darka NAD ee vivo.Sanadkii 2013, Professor David Sinclair oo ka tirsan Dugsiga Caafimaadka Harvard wuxuu ogaaday in da'da, heerka cofactor coenzyme I (NAD+) ee borotiinka cimriga dheer ee jirka uu sii wado inuu hoos u dhaco, taas oo keenta hoos u dhaca shaqada mitochondrial ee "dynamo" unugga, taasoo kicinaysa gabowga. , iyo arrimaha kala duwan ee jirka.Ciladda shaqada noocan ah ayaa sidaas lagu soo saaraa.Sida laga soo xigtay cilmi-baarisyo taxane ah, maadada NAD + ee jidhka bini'aadamka waxay hoos u dhigtaa da'da, taas oo keenta da'da degdegga ah ee da'da 30, oo leh laalaab, nasashada murqaha, baruurta urursan, iyo cudurrada sida wadne xanuunka, dhiig karka, istaroogga. , sonkorowga iyo cudurka Alzheimers ayaa kordhay khatarta.Furaha cimri dhererku waa in la kordhiyo heerka coenzyme I (NAD+) ee jidhka, kordhinta heerka dheef-shiid kiimikaadka unugyada, iyo kicinta firfircoonida dhalinyarada ee suurtagalka ah.
API iyo diyaarinta alaabta ceeriin: NAD + waxaa loo isticmaalaa irbado loogu talagalay daawaynta/xakamaynta maandooriyaha, oo ay ku jiraan NAD IV daawaynta xididada laga hirgaliyay Maraykanka, Yurub, Ruushka, Koonfur Afrika, Mexico, Koonfurta Ameerika, Koonfur Bari Aasiya iyo waddamo kale.Alaabooyinka farmashiyaha iskood isku diyaariya, oo la mid ah farmashiyeyaasha Mareykanka, waxay iibsan karaan alaabada ceyriinka ah si ay naftooda ugu bixiyaan, sida diyaargarowga isbitaallada Shiinaha, waxay koontaroolaan tayada alaabta ceeriin lafteeda, waxayna diyaarisaa diyaarinta daawooyinka.
