β-Nicotinamide adenine dinucleotide phosphate hydrate (NADP)
SyncoZymes (Shanghai) Co., Ltd. waa soo saaraha ugu horreeya iyo alaab-qeybiyaha β-Nicotinamide adenine dinucleotide phosphate hydrate (CAS:53-59-8) oo leh tayo sare. Waxaan ku siin karnaa COA, gaarsiinta adduunka oo dhan, tiro yar iyo tiro badan oo la heli karo. Haddii aad xiisaynayso badeecadan, fadlan noo soo dir macluumaad faahfaahsan oo ay ku jiraan lambarka CAS, magaca badeecada, tirada. Fadlan nala soo xiriir:lchen@syncozymes.com
| Magaca Kiimikada | β-Nicotinamide adenine dinucleotide phosphate hydrate |
| Erayo isku mid ah | β-Nicotinamide adenine dinucleotide phosphate hydrate |
| Lambarka CAS | 53-59-8 |
| Miisaanka Molekulerka | 743.41 |
| Qaacidda Molekuleerigga | C21H28N7O17P3 |
| Lambarka EINECS. | 200-178-1 |
| heerkulka kaydinta. | Ku hay meel mugdi ah, jawi aan firfircoonayn, Ku kaydi qaboojiyaha, ka hooseeya -20°C |
| milmida | H2O: 50 mg/mL, cad, huruud yar |
| pka | pKa1 3.9; pKa2 6.1(heerkulka 25℃) |
| λmax | 260nm (iftiin) |
| Merck | 14,6348 |
| Nidaamka Diiwaangelinta Maandooriyaha ee EPA | Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester oo leh 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, milix gudaha ah (53-59-8) |
| Shayga Tijaabada | Tilmaamaha |
| Muuqaalka | Budada cad ilaa jaalle ah |
| Milmida | 200mg/ml oo biyo ah |
| Qiimaha pH (100mg/ml) | 5.0~7.0 |
| Falanqaynta Muuqaalka UV εat 260 nm iyo pH 7.5 | (18±1.0) × 10³L/mol/cm |
| Tusmada (iyadoo la adeegsanayo falanqaynta ensaymikada ee G6PDH oo pH 7.5 ah, iyadoo la isticmaalayo spectrophotometer, abs.340nm, iyadoo lagu saleynayo biyo aan biyuhu karin) | ≥90.0% |
| Nadiifnimo (iyadoo loo eegayo HPLC, %aagga) | ≥95.0% |
| Biyaha ku jira (sida KF) | ≤5% |
Xirmada:Dhalo, bacda aluminium-ka, 25kg/Durbaan Kaarboor, ama sida waafaqsan shuruudaha macaamiisha.
Xaaladda Kaydinta:Si adag ugu hay meel mugdi ah, si aad u kaydiso muddo dheer, ku hay heerkul ah 2-8℃.
NADP waa coenzyme, kaas oo ah walax ay nicotinamide adenine dinucleotide iyo molecule fosfate ku xidhmaan xidhmo ester ah, oo si ballaaran u jira.adduunka bayoolojiga. Sifooyinka kiimikada, nuugista spectrum, qaabka redox, iwm. waxay la mid yihiin NAD (Coenzyme I). NADP si ballaaran ayaa loogu isticmaali karaa falcelinta.waxaa kiciyay noocyo kala duwan oo alkohol dehydrogenases ah, ketoreductases iyo oxidoreductases kale. Sida: waxaa loo dhimi karaa NADPH iyadoo la adeegsanayo dehydrogenases badan sidasida 6-phosphoglucose dehydrogenase (EC.1.1.1.49), 6-phosphogluconate dehydrogenase (EC.1.1.1.44). Si kastaba ha ahaatee, daruuri ma aha inay la falgasho waxyaabo badan.dehydrogenases-ka isticmaala NAD, mana si toos ah loogu oksijiin karo silsiladda neefsashada. Si ka duwan NAD, waxay inta badan ku jirtaa xaalad yar oo ku jirta unugyada noolaha aerobic-ka.
Sida ku cad isticmaalka badeecada, waxaa loo qaybin karaa darajooyinka soo socda: heerka isbeddelka biotransformation, heerka falcelinta ogaanshaha, heerka cuntada caafimaadka.
Heerka Bayotransformation: Waxaa loo isticmaali karaa isku-darka dhexdhexaadiyeyaasha dawooyinka iyo API-yada, inta badan iyadoo la adeegsanayo ensaymyada katalytic-ga, sida ketoreductase (KRED),P450 monooxygenase (CYP), formate dehydrogenase (FDH), glucose dehydrogenase (GDH), iwm. Sug.
Heerka falgalka ogaanshaha: Iyada oo leh noocyo kala duwan oo ensaymo ogaanshaha ah, sida walxaha cayriin ee xirmooyinka ogaanshaha.
Heerka cuntada caafimaadka leh: Isticmaalka kabka cuntada ee NADP wuxuu inta badan ku jiraa habka cilmi-baarista iyo horumarinta.
