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Oxynitrilases (HNL)
Ku saabsan oxynitrilases
ES-HNLs: Ensaym fasal ah oo si xushmad leh u kiciya ku darista HCN aldehydes (ketones) si loo helo alkoholka cyanide nooca R ama S, kuwaas oo si fudud loogu beddeli karo noocyo badan oo daroogo ama daawooyin ah iyada oo loo marayo habka kiimikada.
Waxaa jira 29 nooc oo ah badeecooyinka oxynitrilase (Lambarka ES-HNL-101～ES-HNL-129) oo ay samaysay SyncoZymes. SZ-HNL waa qalab waxtar leh oo loogu talagalay isku-darka (R)-cyanohydrins ama (S)-cyanohydrins oo ka yimaada noocyo kala duwan oo aldehydes udgoon, aliphatic iyo heterocyclic ah ama xitaa ketones.
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Nitro reductase (NTR)
Ku saabsan nitro reductase
ES-NTRs: Waa flavoenzymes kuwaas oo kiciya hoos u dhigista NAD(P)H-ku-tiirsanaanta kooxaha nitro ee ku jira isku-dhafka nitroaromatic iyo nitroheterocyclic una beddela hydroxylamino iyo/ama amino derivatives. Waxaa si weyn loogu isticmaalaa isku-darka dabiiciga ah ee aromatic hydroxylamine iyo aromatic amine, daaweynta burooyinka, ogaanshaha bayoolojiga iyo burburka wasakhowga deegaanka. Waxaa jira 12 nooc oo ah alaabada Nitro reductase (NTR) (Lambarka sida ES-NTR-101~ES-NTR-112) oo ay samaysay SyncoZymes.
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Aldolase (DERA)
ES-DERAs: Waxay si wax ku ool ah u kicin kartaa ku darista stereoselective ee ketones deeq-bixiyeyaasha aldehydes-ka qaataha. Intaa waxaa dheer, falcelinta waxaa lagu samayn karaa xal biyood oo pH dhexdhexaad ah iyada oo aan la isticmaalin tallaabooyin ilaalin gaar ah. Waxay ka tirsan yihiin fasalka I aldolase, kaas oo sameeya saldhigga Shiff ee habka katalytic-ga. Substrate-ku wuxuu si isku xiran ugu xiran yahay kooxda amino ee goobta firfircoon si uu u bilaabo jabka iyo sameynta xiriirka. Farqiga u dhexeeya DERAs iyo aldolases kale ayaa ah in substrate-yada ay katalysiiyaan ay yihiin aldehydes waxayna mari karaan isku-darka aldehydes ee joogtada ah.
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Cytochrome P450 monooxygenase (CYP)
Ku saabsan CYP
ES-CYPs: Nooc ka mid ah ensaymada redox oo leh mercaptan-heme oo ah xarunta firfircoon si loo kiciyo wareejinta oksijiinta. Waa oksijiin-ka-baxa ee terminal-ka waxayna u baahan yihiin heme si ay u dhaqaajiso oksijiinta.
Cytochrome P450 monooxygenase wuxuu kiciyaa oksaydhka, epoksaydhka iyo hydroxylation ee alkyl, hydroxylation iyo oksaydhka ammonia, oksaydhka sulfur, dealkylation (oxygen, sulfur, ammonia), oksaydhka dehydrogenation, deamination iyo dehalogenation.
Waxaa jira 8 nooc oo ah badeecooyinka cytochrome P450 monooxygenase (Lambarka ES-CYP-101～ES-CYP-108) oo ay samaysay SyncoZymes.Moobayl/Wechat/WhatsApp: +86-13681683526
Iimayl:lchen@syncozymes.com
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Oksaydh-ka khamriga (AOX)
Ku saabsan oksaydhka khamriga
ES-AOXs: Ensaymyadani waxay awood u leeyihiin inay kiciyaan oksaydhaynta alkolada dufanka leh ama aryl-alcohols si ay u sameeyaan aldehydes. Waxay isticmaalaan oksijiin molecular laakiin uma baahna cofactor dibadda lagu daray, oo hydrogen peroxide la soo saaro.
Waxaa jira 6 nooc oo ah alaabada alkohol oxidases (Lambarka ES-AOX-101~ES-AOX-106) oo ay samaysay SyncoZymes. ES-AOX101 iyo ES-AOX102 waxay doorbidaan substrates-ka alkoholka aliphatic, ES-AOX103~ ES-AOX105 waxay doorbidaan substrates-ka alkoholka udgoonka leh, ES-AOX106 waa oxidase-ka kolestaroolka. SZ-AOX waa qalab waxtar leh oo lagu kicinayo oksaydhka alkoholka dufanka leh ama alkoholka aryl si loo soo saaro aldehydes.
Nooca falgalka kicinta:
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D-Aamino acid dehydrogenase (D-AADH)
Ku saabsan dehydrogenase-ka D-Amino acid
ES-D-AADH (D-Amino acid dehydrogenase): ensaym yareeya aashitada 2-keto una beddela aashitada D-amino ee u dhiganta. Falgalku wuxuu u baahan yahay NADP(H) iyo deeq-bixiye aashitada aan dabiiciga ahayn (sida aashitada ...
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Esterase iyo Lipase (PLE&CALB)
Ku saabsan Esterase & Lipase
ES-PLES: Nooc ka mid ah hydrolases-ka kaas oo kiciya sameynta iyo jabka xidhmooyinka ester-ka. Waxay ka qayb qaadan karaan noocyo badan oo falgallo bayooloji ah, sida esterification, transesterification iyo hydrolysis. Waxaa si weyn loogu isticmaalaa dhinacyo badan sida habaynta cuntada, warshadaha kiimikada, bayomedicine, daawada chiral iyo daaweynta deegaanka.
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Epoxide hydrolase (EH)
Ku saabsan epoksaydh hydrolase
EH waa hydrolase ether kaas oo kiciya hydrolysis-ka stereoselective ee epoksidyada racemic si loo soo saaro 1, 2-diol iyo epoxides firfircoon oo indhaha ah, kuwaas oo loo isticmaali karo xallinta chiral ee epoksidyada ama diyaarinta chiral diols. Waxaa si weyn loogu isticmaalaa daawada iyo meelaha kale. Waxaa jira 3 nooc oo ah alaabada epoxide hydrolases (Lambarka sida ES-EH-101～ES-EH-103) oo ay samaysay SyncoZymes. ES-EH waa qalab waxtar leh oo lagu kicinayo isku-darka alkohols-ka chiral iyada oo loo marayo hydrolysis stereoselective ah oo ah epoksidyada aliphatic iyo aromatic.
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Qaabaynta dehydrogenase (FDH)
Ku saabsan Formate dehydrogenase
ES-FDH (Format dehydrogenase): FDH waxay kicisaa baabi'inta ammonium format si ay u soo saarto kaarboon laba ogsaydh iyo ammonia, waxayna NAD u yareysaa NADH iyadoo NAD u ah soo-dhoweeyaha elektarooniga ah. FDH waxaa badanaa loo isticmaalaa dib u soo nooleynta coenzyme NADH. Waxaa jira 4 nooc oo ah alaabada enzyme-ka FDH (ES-FDH-101~ES-FDH-104) oo ay samaysay SyncoZymes, kuwaas oo ES-FDH102 ay leedahay waxqabadka ugu sarreeya waana FDH-ga inta badan lagu taliyay.
Nooca falgalka kicinta:
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Gulukooska dehydrogenase (GDH)
Ku saabsan Gulukooska dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH wuxuu kiciyaa baabi'inta gulukooska si uu u soo saaro gluconic acid (lactone), wuxuuna yareeyaa NAD(P)+ ilaa NAD(P)H, iyadoo NAD(P)+ uu yahay soo-dhoweeyaha elektarooniga ah. GDH waxaa badanaa loo isticmaalaa dib u soo nooleynta coenzyme NAD(P)H ee goobaha biocatalysis iyadoo la adeegsanayo ensaym kale oo weyn. Waxaa jira 10 nooc oo ah alaabada ensaymka GDH (ES-GDH-101~ES-GDH-110) oo ay samaysay SyncoZymes, kuwaas oo ES-GDH110 ay leedahay waxqabadka ugu sarreeya waana GDH-ga ugu badan ee lagu taliyay.
Nooca falgalka kicinta:
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Oxidase-ka Monoamine (MAO)
Ku saabsan Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO waxay kicisaa baabi'inta oksaydhka ee monoamines si ay u soo saarto hydrogen peroxide, ammonia iyo aldehydes u dhigma. Habka kicinta, oksijiin ayaa lagama maarmaan u ah oksaydh ahaan. Waxaa jira 6 nooc oo ah alaabada ensaymka MAO (Lambarka sida ES-MAO-101～ES-MAO-106) oo ay samaysay SyncoZymes, kaas oo loo isticmaali karo baabi'inta oksaydhka ee isku-dhafka monoamine.
Nooca falgalka kicinta:
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Lactate Dehydrogenase (LDH)
Ku saabsan Lactate dehydrogenase
Waxaa jira 1 nooc oo ah wax soo saarka ensaymka LDH (Lambarka sida ES-LDH) oo ay samaysay SyncoZymes. LDH waxay kicin kartaa dhimista pyruvate una beddelaysaa L-lactic acid, ama dhimista asiidhyada kale ee α-keto ee la midka ah. Inta lagu jiro habka katalisnimada, NADH waa lagama maarmaan sida qaadaha haydarojiin.
Nooca falgalka katalytic-ga ee lactate dehydrogenase
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